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This occurs when pressure changes cause water to flow backward through pipes

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Secondary outcomes are the safety of SAMe administration (incidence of serious adverse events), change from baseline in cognitive performance (as measured by the Repeatable Battery for the Assessment of Neuropsychological Status), and epigenetic changes in DNA methylation

Masters BA, Kelly EJ, Quaife CJ, Brinster RL, Palmiter RD: Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium